Epicel product culture

Using Epicel

Epicel is indicated for the treatment of deep dermal or full thickness burns comprising a total body surface area greater than or equal to 30%

Consider Epicel for the following patient types

Large Burns
>30% TBSA

Use Epicel over autograft for superior take rate and durability

Treatment

Apply Epicel over autograft meshed at 4:1– 6:1 ratio for best results in durability, take rate and cosmesis5

Limited Suitable Harvest Sites

Use Epicel to achieve naturalized signalizing using the patient's own skin

Treatment

If no autograft is available, apply Epicel directly over well-engrafted and vascularized allodermis/other dermal substitutes

Autograft for key functional areas

Use Epicel to maximize donor skin for functional areas

Treatment

Use Epicel to conserve autograft for use on critical areas meshed at a lower ratio (face, hands and joints)

Clinical identifiers for the Epicel patient

  • Limited, overtaxed or unsuitable harvest sites, including fragile skin (pediatric, geriatric)
  • Undesirable or limited quality skin (soles of feet, face, scalp, scattered small sites)
  • Concomitant injuries or disease which may impact healing (diabetes mellitus, cardiovascular disease)
  • A history of skin conditions that may impede autograft (skin cancer, psoriasis, eczema, keloid scarring)
  • A need to limit donor reharvesting procedures

Epicel pre-grafting

Use Epicel in conjunction with autograft

Epicel can support the use of wide-mesh autograft from 4:1 up to 6:1

Healing occurs as the meshed autograft spaces fill in with cultured epidermis

A CEA/wide mesh autograft combination may increase the initial durability of Epicel4

Donor sites may also be covered with Epicel to accelerate reharvest potential6

meshed autograft
Widely meshed autograft, prior to placement of Epicel
graft treatment, 4 months post surgery autograft
Epicel-treated patient
4 months post surgery

Skin graft dimensions - 6cm x 2cm

Taking an Epicel biopsy within 48 hours of admission can increase the option to use Epicel later in treatment

Taking the Biopsy

The autologous keratinocytes used to prepare Epicel (cultured epidermal autografts) are derived from two small, full-thickness biopsies of skin taken from an unaffected area on the burn patient

Epicel over time

By using a patient's own multi-layer skin, once engrafted
Epicel can provide the patient with functional tissue3

meshed autograft
Epicel-treated patient 2 months post surgery
graft treatment, 4 months post surgery autograft
Epicel-treated patient 12 months post surgery

A Vericel Cell Therapy Specialist will be available for surgery

Click Here to Download the Epicel Surgical Guidelines

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Epicel: a scientific overview

Call the Epicel reimbursement support hotline to speak with our reimbursement experts

Epicel is widely reimbursed and included on a majority of national insurance plans.
Click here to learn more about Epicel reimbursement